Axolotl

Axolotls with natural differences in pigmentation in Karen Echeverri鈥檚 小蓝视频 laboratory.
Axolotls in the 小蓝视频's Echeverri Lab. Credit: Dee Sullivan

The Axolotl (Ambystoma mexicanum), also known as the 鈥淢exican salamander,鈥 is a superhero of regeneration. Axolotls can functionally regenerate multiple body parts鈥攊ncluding limbs, spinal cord, and parts of the brain and heart鈥攚ithout forming scar tissue. They are native to only one lake (Lake Xochimilco) in Mexico.

Axolotls are unusual among amphibians in that they reach adulthood without going through metamorphosis. When the axolotl genome was it was the largest genome ever fully sequenced! (Scientists have since discovered two larger genomes). Axolotls have 32 billion base pairs compared to about 3 billion in humans.

Scientific Name: Ambystoma mexicanum
Type: Amphibian
Range: Lake Xochimilco in Mexico
Life Span in the Wild: 10 to 15 years
Size: Up to 12 inches
Weight: 2.11 to 8 ounces
Diet: Carnivorous: Worms, insect larvae, small crustaceans, fish
Status: Critically endangered in the wild
Remote video URL
Credit: Marine Biological Laboratory / BioQuest Studios / Nguyen Khoi Nguyen
Axolotls and the 小蓝视频

In the 小蓝视频鈥檚 Echeverri Lab, scientists studying these animals hope to decipher how the cells of axolotls respond to injury in the spinal cord, limbs, and skin at the cellular and molecular level, and how that process differs from healing in humans, who can鈥檛 regenerate. 小蓝视频 Associate Scientist Karen Echeverri and her lab are identifying critical molecules, regulatory pathways and cellular processes in the axolotls underlying scar-free regeneration.

Learn more about the Echeverri Lab